🧠DIFFERENTIALS + 3 MOST COMMON CHIEF COMPLAINTS (Layman’s Words)
(Each differential = exactly 3 complaints, short & simple)
1. Schizophrenia
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“I hear voices talking to me.”
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“People are plotting against me.”
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“I don’t feel like doing anything or talking to anyone.”
2. Acute & Transient Psychotic Disorder (ATPD)
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“Something suddenly happened — I’m seeing things that aren’t real.”
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“People are after me; I need to run.”
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“I haven’t slept at all for 2–3 days.”
3. Bipolar Mania
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“I have too much energy; I don’t feel tired at all.”
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“I’m talking a lot and my thoughts keep running.”
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“I feel unusually happy or irritated without reason.”
4. Bipolar Depression
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“I don’t feel like living or doing anything.”
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“I feel tired all the time.”
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“I can’t concentrate on anything.”
5. Major Depressive Disorder
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“I feel sad all the time.”
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“I can’t enjoy anything anymore.”
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“I don’t feel like eating or getting out of bed.”
6. Delirium
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“He is not recognizing us.” (family reports)
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“He keeps saying strange, confused things.”
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“He becomes more restless at night.”
7. Substance-Induced Psychosis (e.g., Cannabis)
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“I’m hearing voices after taking ganja.”
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“I feel extremely scared; something bad will happen.”
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“I feel like people are watching me.”
8. Alcohol Withdrawal / Delirium Tremens
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“My hands are shaking when I stop drinking.”
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“I’m seeing insects or shadows that aren’t real.”
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“I feel extremely anxious and sweaty.”
9. Obsessive–Compulsive Disorder (OCD)
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“I keep getting unwanted thoughts that I can’t stop.”
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“I have to repeat checking/washing again and again.”
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“If I don’t do it, I feel very tense.”
10. Panic Disorder
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“Suddenly my heart starts racing and I feel like I will die.”
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“I can’t breathe properly during these attacks.”
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“These attacks come out of nowhere.”
11. Generalized Anxiety Disorder
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“I keep worrying about everything, all the time.”
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“I feel tense and restless throughout the day.”
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“I can’t sleep because of overthinking.”
12. PTSD
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“I keep getting memories of that incident again and again.”
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“I get nightmares about it.”
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“I avoid anything that reminds me of it.”
13. Somatic Symptom Disorder
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“I have pain everywhere but no one finds anything.”
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“I’m always tired and sick.”
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“My health worries don’t go away.”
14. Conversion Disorder
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“I suddenly cannot move my arm/leg.”
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“I suddenly cannot speak.”
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“I faint or have fits when stressed.”
15. Dementia (Alzheimer’s type)
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“I keep forgetting recent things.”
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“I ask the same question again and again.”
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“I get lost even in familiar places.”
16. Depression with Psychotic Features
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“I feel extremely hopeless.”
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“I hear a voice saying I’m worthless.”
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“I believe my body is rotten or I deserve punishment.”
17. Personality Disorder (Borderline)
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“My mood changes suddenly without control.”
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“I often hurt myself when upset.”
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“People leave me; I feel abandoned.”
18. ADHD (Adults)
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“I can’t focus on anything for long.”
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“I keep losing things and forgetting work.”
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“I act on impulse without thinking.”
19. Autism Spectrum Disorder (Adolescent/Young Adult presentation)
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“I don’t understand social cues or conversations.”
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“I like repeating routines.”
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“I get very upset with small changes.”
20. Epilepsy-related Psychosis (Post-ictal)
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“He is behaving strangely after a seizure.” (family)
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“He hears voices and speaks oddly after fits.”
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“He becomes scared or confused for many hours.”
21. Anti-NMDAR / Autoimmune Encephalitis (Psychiatric presentation)
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“She suddenly started talking strangely.”
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“She is seeing things that aren’t there.”
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“She becomes confused and behaves child-like.”
22. Hypothyroidism (Psychiatric presentation)
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“I feel very tired and sleepy.”
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“I feel low and slow in everything.”
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“I’m gaining weight and feel mentally dull.”
23. Hyperthyroidism (Psychiatric presentation)
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“My heart beats fast all the time.”
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“I feel very anxious and shaky.”
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“I cannot tolerate heat and sweat a lot.”
24. Opioid Withdrawal
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“I have severe body aches when I stop taking smack / brown sugar.”
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“I feel restless and can’t sleep.”
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“I have loose motions and a runny nose.”
25. Chronic Pain with Depression
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“My pain doesn’t go away no matter what I take.”
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“It is affecting my daily life.”
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“I feel hopeless because of this.”
1. Low Mood / Depression
Key Questions
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When did the low mood start? Sudden or gradual?
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Was there any triggering event?
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Is the low mood continuous or episodic?
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Do you still enjoy things you previously liked? (Anhedonia)
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How is your energy level?
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Any feelings of hopelessness, guilt, worthlessness?
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Any crying spells?
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How is your sleep? (Early morning awakening?)
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How is your appetite and weight?
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Any suicidal thoughts? Plans? Past attempts?
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Effect on functioning: work, study, interpersonal relationships.
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Any previous depressive episodes?
2. Anxiety / Generalized Anxiety
Key Questions
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What are you most worried about?
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How long have you been experiencing excessive worry?
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Is the worry difficult to control?
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Associated symptoms: restlessness, tension, sweating, palpitations?
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Any physical symptoms (GI upset, headache, tremors)?
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Does anxiety affect sleep?
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Impact on daily functioning.
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Any avoidance behaviour?
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Any previous anxiety episodes or treatment?
3. Panic Attacks
Key Questions
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Describe exactly what happens during the episode.
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Sudden onset? Peak within minutes?
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Symptoms: palpitations, sweating, choking, breathlessness, chest pain, fear of dying?
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Duration of each episode?
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Frequency of attacks?
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Situational or unexpected?
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Any anticipatory anxiety between attacks?
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Any avoidance of places due to fear of attacks?
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History of ER visits thinking it was a heart attack?
4. Phobias (Social, Specific, Agoraphobia)
Key Questions
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What specific situation/object causes fear?
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What thoughts occur during exposure?
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Degree of avoidance?
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Physical symptoms associated?
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Does the patient recognize fear as excessive?
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Impact on daily and social functioning.
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Duration of problem.
5. Psychosis (Suspiciousness, Hallucinations, Disorganized Behaviour)
Hallucinations
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Do you hear voices when no one is around?
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Do the voices talk to you, about you, or give commands?
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Are the voices inside your head or outside?
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Frequency and duration?
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Distress caused?
Delusions / Suspiciousness
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Do you feel someone is trying to harm you?
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Any belief that others are watching, spying, following you?
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Do you have unusual beliefs about yourself or the world?
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Are you able to explain why you believe this?
Thought & Behaviour
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Any difficulty in organizing thoughts?
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Talking to oneself?
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Social withdrawal?
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Neglect of self-care?
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Aggressive or erratic behaviour?
Course
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Onset: acute or insidious?
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Progression? First episode?
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Any substance use related to onset?
6. Substance Use Disorder
Alcohol / Drugs
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What substances are you using? (Type, route)
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Quantity and frequency?
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Pattern (daily, binge, weekend)?
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Craving present?
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Loss of control over use?
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Withdrawal symptoms (tremors, sweating, anxiety, seizures)?
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Any blackouts?
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Any previous quit attempts? Why unsuccessful?
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Impact on occupation, family, finances.
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Any legal problems?
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Co-use of multiple substances?
7. Suicidal Ideation / Attempt
Assessment Questions
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What thoughts of self-harm or suicide have you had?
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Do you have a plan? Means available?
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Intention to die at the time?
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What prevented you from acting?
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Past attempts? Methods used?
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Triggers or stressors?
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Feelings of hopelessness or burdensomeness?
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Any substance use during the event?
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Current suicidal intent (very important).
8. Somatic Symptom Disorder / Functional Symptoms
Key Questions
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What physical symptoms are troubling you?
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How long have they been present?
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Do symptoms shift from one body part to another?
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Any excessive preoccupation or fear regarding illness?
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How much time per day do you think about illness?
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Have you consulted multiple doctors?
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Any tests already done?
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Effect on daily functioning.
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What explanation does the patient believe?
9. Conversion Disorder
Key Questions
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Exactly describe the symptom (paralysis, non-epileptic seizures, sensory loss).
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Onset and progression?
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Preceding stress or conflict?
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Sudden or gradual?
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Inconsistency between complaint and examination?
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Any past similar episodes?
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Patient attitude (la belle indifférence)?
10. OCD (Obsessions & Compulsions)
Obsessions
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What repetitive, intrusive thoughts trouble you?
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Do they feel unwanted and excessive?
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How much time spent per day thinking about them?
Compulsions
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What behaviours do you repeat? (Checking, washing, counting)
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What happens if you resist performing them?
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Duration and frequency of rituals.
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Degree of distress and interference.
11. Cognitive Decline / Dementia
Key Questions
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What memory problems are you noticing? (Recent vs remote)
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Repetition of questions?
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Difficulty performing routine tasks?
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Getting lost in familiar places?
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Personality or behaviour changes?
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Disturbance in sleep/wake cycle?
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Onset: sudden vs insidious.
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Any strokes, head injury, alcohol use?
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Impact on ADLs/IADLs.
12. Mania / Mood Elevation
Key Questions
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Elevated or irritable mood? Duration > 1 week?
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Increased energy and activity?
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Reduced need for sleep?
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Excessive talking / pressured speech?
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Racing thoughts?
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Increased involvement in risky activities?
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Increased spending, hypersexuality?
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Grandiosity?
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Past manic/hypomanic episodes?
13. Insomnia / Sleep Problems
Key Questions
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Difficulty initiating or maintaining sleep?
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Early morning awakening?
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Sleep quality and duration?
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Daytime sleepiness?
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Stressors or worrying thoughts at bedtime?
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Use of caffeine, nicotine, stimulants?
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Snoring or apnea symptoms?
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Sleep–wake routine.
14. Aggression / Irritability
Key Questions
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Nature: verbal or physical aggression?
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Triggers?
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Frequency and severity?
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Substance use involved?
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Impulsivity?
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Harm to self or others?
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Insight into behaviour?
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History of violence?
15. Child Psychiatry (ADHD / ASD / Poor Scholastic Performance)
ADHD
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Inattention symptoms (careless mistakes, easily distracted).
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Hyperactivity (running, fidgeting).
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Impulsivity (interrupting, blurting out).
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School performance and teacher complaints.
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Onset before 12 years?
ASD
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Eye contact? Social reciprocity?
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Speech delay?
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Repetitive behaviours?
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Restricted interests?
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Sensory sensitivities?
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